Why Air Pollutants Make Some People Vulnerable to Atopic Dermatitis (IMAGE)

Tohoku University

Why Air Pollutants Make Some People Vulnerable to Atopic Dermatitis

Caption

Schema of AhR-mediated development and exacerbation of atopic dermatitis. AhR is activated by air pollutants, such as traffic-derived particulate matter (pm2.5). Activated AhR induces the expression of artemin in keratinocytes, which induces hyper-innervation of the epidermis, resulting in hypersensitivity to itch. Subsequent scratching leads to barrier damage and increased penetration of antigens, which enhances sensitization that promotes a predisposition to other allergic diseases.

Credit

Hidaka et al., 2016

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Credit: Hidaka et al., 2016

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