Amity Manning andConor Herlihy, Worcester Polytechnic Institute (IMAGE)
Caption
Amity Manning, left, assistant professor of biology and biotechnology at Worcester Polytechnic Institute (WPI), and Conor Herlihy, a PhD candidate in biology and biotechnology, review images of cells undergoing mitosis in the absence of the protein pRB, which she has shown plays a critical role in assuring that the chromosomes are correctly segregated when a cell divides. The cells have been engineered to express fluorescently labelled proteins, which make the chromatin (the complex of proteins and genetic material that make up chromosomes) appear blue and the microtubules (the structure that actually separates the chromosomes) appear red. Manning's team is exploring how errors in chromosome segregation in cancer cells in the absence of pRB may contribute to genetic variability and chemotherapy resistance in tumors.
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Worcester Polytechnic Institute (WPI)
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