Variations in Gene ATAD3A Can Result in Less Mitochondria (IMAGE)

Baylor College of Medicine

Variations in Gene ATAD3A Can Result in Less Mitochondria

Caption

Motor neurons of Drosophila showing that expression of variant p.Arg534Trp of the fly's equivalent of human ATAD3A gene causes a decrease in the number of mitochondria (green). Top row, control; middle row, motor neurons with normal (wild type) fly's equivalent of human ATAD3A gene; bottom row, motor neurons with variant R534W of the fly's equivalent of human ATAD3A gene. VNC, ventral nerve cord; Neurons are labeled in blue and boutons, an area of synapsis with another neuron, in red.

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Courtesy of J. Lupski, H. Bellen, T. Harel and W.H. Yoon/The American Journal of Human genetics

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