New Stem Cell-Based Screen Reveals Promising Drug for Lou Gehrig's Disease (IMAGE)

Cell Press

New Stem Cell-Based Screen Reveals Promising Drug for Lou Gehrig's Disease

Caption

The c-Jun-mediated cell death pathway (marked by red nuclei that are positive for phospho-cjun) is activated in stem cell-derived motor neurons (green) exposed to trophic factor withdrawal (upper left panel). C-Jun activation and cell death are blocked by kenpaullone, an inhibitor GSK-3 and HGK (MAP4K4) kinases (lower right panel; kenpaullone structure superimposed).

Credit

<i>Cell Stem Cell</i>, Yang et al.

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