Neuron and imaging (IMAGE)

University of Göttingen

Neuron and imaging

Caption

Chronic 2-photon imaging of fluorescently labelled visual cortical neurons in the living adult mouse brain: within the first 4 days of imaging, from day 0 (d0) to day 4 (d4), one dendritic spine (white dendritic protrusion) was newly formed (green arrow); after selective visual stimulation over the next 4 days (until d8), the spine was eliminated (red arrow). White arrow points to a stable spine. Dendritic spine elimination in this paradigm is usually only seen in juvenile mice, but also observed in adult PSD-95 deficient neurons, indicating that PSD-95 is necessary for synapse maturation and stabilization.

Credit

S Löwel

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