Elomere Alterations in NF1-Solid Tumors (IMAGE)

Johns Hopkins Medicine

Elomere Alterations in NF1-Solid Tumors

Caption

'Telomere alterations in NF1-solid tumors. NF1-associated gliomas demonstrated telomeres of normal length (a), long (comparted to internal non-neoplastic cells, arrows) (b) or ALT (arrows) (c). ALT was relatively frequent in NF1-associated gliomas, and associated with a worse prognosis, while the majority of evaluable ALT negative gliomas had normal or abnormally long telomeres. In contrast, MPNST demonstrated telomeres of normal length (comparted to internal non-neoplastic cells, arrows) (d), short (comparted to internal non-neoplastic cells, arrows) (e) or ALT (arrows) (f). '

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Acta Neuropathologica Communications

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