Toxin Chimeras Slip Therapeutics Into Neurons to Treat Botulism in Animals (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

Toxin Chimeras Slip Therapeutics Into Neurons to Treat Botulism in Animals (1 of 1)

Caption

Schematic showing how the chimera molecule (BoNT/XA) delivers nanobodies to neurons to neutralize botulism neurotoxins. This material relates to a paper that appeared in the Jan. 6, 2021, issue of <i>Science Translational Medicine</i>, published by AAAS. The paper, by S.-I. Miyashita at Boston Children's Hospital in Boston, MA; and colleagues was titled, "Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism."

Credit

[Credit: S.-I. Miyashita <i>et al., Science Translational Medicine</i> (2021)]

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