The Mendelian Randomization Results for Proteins on Human Diseases (IMAGE)

University of Bristol

The Mendelian Randomization Results for Proteins on Human Diseases

Caption

Comparing the genetic inferred causal relationships of proteins on human diseases with historic drug development programs, this study, for the first time, showed that protein-disease pairs with genetic predicted causal evidence is more likely to be approved drugs for the same indications. To support open science, the working group built up a graphical database, EpiGraphDB Proteome PheWAS browser (www.epigraphdb.org/pqtl/), which makes the over 220,000 pairs of protein-disease associations openly accessible to the public. The team also shared the analysis protocol with public via GitHub (https://github.com/MRCIEU/epigraphdb-pqtl).

Credit

Dr Jie Zheng

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