Visual Abstract (IMAGE) University of Eastern Finland Caption The induced pluripotent stem cell (iPSC) -derived microglia demonstrate that apolipoprotein E4 (APOE4) has a profound impact on several functions of human brain immune cells that could explain mechanisms behind Alzheimer's disease. Credit Henna Konttinen Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.