SARS-CoV-2 PLpro Inhibitors (IMAGE)

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SARS-CoV-2 PLpro Inhibitors

Caption

This study compared the potency of a collection of SARS-CoV-2 PLpro inhibitors and identified the most potent compound GRL-0617 with the IC50=2.2 μmol/L. Subsequently, the authors revealed the binding mode of GRL-0617 with the protease using crystallographic approach, providing a framework for further inhibitor development targeting SARS-CoV-2 PLpro.

Credit

Acta Pharmaceutica Sinica B

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