Aneuploidy -- Causes and Consequences (3 of 9) (IMAGE)

American Association for the Advancement of Science (AAAS)

Aneuploidy -- Causes and Consequences (3 of 9)

Caption

Visualization of a cancer cell dividing using Hoechst stain that binds to genomic DNA in the cell nucleus. A human cancer cell in the anaphase stage of mitosis can be seen in the center of the image with sister chromatids pulling apart into two daughter cells. STAG2 is a component of the “cohesin complex” that regulates the cohesion of sister chromatids ensuring their faithful segregation during mitosis. Several interphase cells not in the process of dividing can also be seen. This image relates to an article that appeared in the Aug. 19, 2011, issue of Science, published by AAAS. The study, by Dr. D.A. Solomon of the Georgetown University School of Medicine in Washington, D.C., and colleagues was titled, "Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer."

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