MADM in the Snow Brain (IMAGE)

Institute of Science and Technology Austria

MADM in the Snow Brain

Caption

The image shows a brain shaped bench (designed by Austrian artist Peter Kogel) on the IST Austria campus, reflecting an artistic representation of a MADM (Mosaic Analysis with Double Markers) brain. Snowflakes covering the bench represent the vast amount of non-labelled cells, and the colorful water balloons illustrate a very sparse genetic mosaic of neurons and glia. The differentially labelled cell populations can contain mutations for a gene of interest. By exploiting MADM-based genetic mosaics with high single cell resolution Beattie et al. discovered distinct but sequential functions of Lgl1 controlling cortical embryonic neurogenesis, postnatal astrocyte- and olfactory bulb interneuron generation. (Photograph by Maria Cristina Travaglio).

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Maria Cristina Travaglio

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