HIV-1 Can Escape Cas9/sgRNA-Mediated Inhibition (IMAGE)

Cell Press

HIV-1 Can Escape Cas9/sgRNA-Mediated Inhibition

Caption

This visual abstract depics how HIV-1 can escape Cas9/sgRNA-mediated inhibition. The researchers reveal that the NHEJ repair machinery generates mutations in the HIV-1 Cas9 cleavage site that result in two outcomes: viral replication suppression and viral escape.

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Wang et al./<i>Cell Reports</i> 2016

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