Engineered Antibody Challenges 'One Lock, One Key' Dogma (1 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

Engineered Antibody Challenges 'One Lock, One Key' Dogma (1 of 3)

Caption

3-D structures of the two-in-one antibody modeled as a full-length antibody (an immunoglobulin G, IgG) with each of its two antigen-binding arms capable of binding either of its two antigens. This image accompanied the report "Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site," by J. Bostrom et. al. appearing in the March 20, 2009 issue of Science.

Credit

Image generated by Allison Bruce and Jenny Bostrom, via <i>Science</i>-AAAS

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Please cite the owner of this image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</I> for permission.

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