Some Oligodendrocytes Selectively Myelinate Axons from a Particular Brain Region (IMAGE)
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The research group established a novel method for detecting the axons myelinated by a single oligodendrocyte. This method uses three kinds of viral vectors to label axons derived from multiple brain regions and oligodendrocytes in the white matter. Using this method, they found that some populations of oligodendrocytes in the corpus callosum selectively myelinated axons derived from motor cortex or sensory cortex. Moreover, the newly established method is a versatile tool for analyzing precise morphology of each oligodendrocyte in animal models of demyelinating disorders and addressing the role of oligodendrocyte in higher brain functions.
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