Central Mechanisms of Salt-Induced BP Elevations (IMAGE)

National Institutes of Natural Sciences

Central Mechanisms of Salt-Induced BP Elevations

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Increases in blood and CSF [Na+] activate Nax in the OVLT, and induce lactate (Lac-) and H+ release from Nax-expressing ependymal cells through MCT. The resultant extracellular acidification (H+) stimulates OVLT(?PVN) neurons via ASIC1a activation. The OVLT-PVN-RVLM neural pathway is then activated and elevates BP through increases in SNA. From Nomura et al., 2018, Neuron (DOI: 10.1016/j.neuron.2018.11.017).

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