Immune Disease and Open Chromatin (IMAGE)

Cincinnati Children's Hospital Medical Center

Immune Disease and Open Chromatin

Caption

In this image from a study in the Journal of Experimental Medicine, the genome browser screen shot at top shows locations of open chromatin in T cells where transcription factors bind to help the immune cells develop. Color peaks show sites of chromatin opening to facilitate binding. The bottom heat map below shows the presence of the molecule H3K4me2 in the T helper cells of asthma patients and healthy control patients. H3K4me2 is associated with chromatin opening in the nucleus of T helper cells. Researchers looking for improved immune disease treatments report finding a molecular key to the body making healthy T cells.

Credit

Cincinnati Children's

Usage Restrictions

Please credit Cincinnati Children's

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.