ETC-159 (IMAGE)

Duke-NUS Medical School

ETC-159

Caption

The team found that Wnt/beta-catenin pathways activate MYBL2 in the nucleus, which regulates several DNA repair genes. In healthy people, this helps maintain stem cells from accumulating mutations. But it can also help some cancers resist DNA damage by PARP inhibitors. These patients could benefit from receiving a drug that blocks this process along with the PARP inhibitor, such as ETC-159.

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Duke-NUS Medical School

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