ETC-159 (IMAGE) Duke-NUS Medical School Caption The team found that Wnt/beta-catenin pathways activate MYBL2 in the nucleus, which regulates several DNA repair genes. In healthy people, this helps maintain stem cells from accumulating mutations. But it can also help some cancers resist DNA damage by PARP inhibitors. These patients could benefit from receiving a drug that blocks this process along with the PARP inhibitor, such as ETC-159. Credit Duke-NUS Medical School Usage Restrictions Image may only be used with the provided caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.