Model for the Evolution of Compartmentalization (IMAGE)
Caption
This is a schematic highlighting the possible evolutionary transitions in protein-coding genes underlying the prokaryote- to-eukaryote transition in light of the Lokiarchaeum genome. The putative archaeal host existed in a stable symbiotic relationship with one or more bacterial species, with the capacity for both gene and lipid exchange between species. The archaeal host, with a large complement of cytoskeletal genes and regulatory GTPases, was probably capable of complex shape regulation. The transition to compartmentalization and a eukaryotic cellular organization was facilitated by: (i) the ability to lipidate GTPases; (ii) the coupling of SNARE and longin domains; and (iii) the acquisition of dynamins and CopII-like coatamer proteins.
Credit
Dey et al./<I>Trends in Cell Biology</I> 2016
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