New discovery for how the brain 'tangles' in Alzheimer's Disease (IMAGE)
Caption
In a paper of <i>Acta Neuropathologica</i> this month, Polanco et al. demonstrate that following internalization exosomes can deliver misfolded tau into the cytosol via permeabilization of endolysosomes in HEK293T and neuronal cells. Pictured is a 3D reconstruction using deconvoluted Z-series of a cultured neuronal cell showing permeabilized endosomes (red, mCherry-Gal3), exosomes (green, CD9-mEmerald) and nucleus (blue). Overlaid is a sliced half of the 3D surface rendering used to mask images for colocalization analysis.
Credit
Dr Juan Polanco et.al, The University of Queensland
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