New Trick Tunes into Translation (IMAGE)

American Association for the Advancement of Science (AAAS)

New Trick Tunes into Translation

Caption

Early stage oocytes show osk-TRICK reporter mRNA labeled by both NLS-PCP-GFP (green) and NLS-MCP-RFP (red). The first round of translation displaces NLS-PCP-GFP from the oskTRICK transcript as the ribosome traverses the coding region that contains the PP7 binding sites, resulting in the loss of NLS-PCP-GFP fluorescent signal in later stage oocytes. This material relates to a paper that appeared in the March 20, 2015 issue of Science, published by AAAS. The paper, by J.M. Halstead at Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, and colleagues was titled, "An RNA biosensor for imaging the first round of translation from single cells to living animals."

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[Credit: Frank Wippich, EMBL]

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