Photomicrographs of Mouse Tumors (IMAGE)
Caption
Photomicrographs of mouse tumors expressing a factor that suppresses a local immune response (left) and one that permits that immune response (right). Researchers discovered that cancer cells expressing the protein CCR2 suppress the secretion of factors that cause dendritic cells to infiltrate and mature in tumors. The image on the left shows where the cancer cells (colored green) have the CCR2 protein and this tumor has few dendritic cells (colored red). The image on the right shows a tumor where the cancer cells do not have the CCR2 protein, and this tumor is infiltrated by many more dendritic cells. Cell nuclei are stained blue in both images.
Credit
Xue-Yan He, Egeblad lab, CSHL.
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