Disrupting Cancer's DNA (IMAGE)

Cincinnati Children's Hospital Medical Center

Disrupting Cancer's DNA

Caption

This microscopic photo shows that an experimental small-molecule compound called 6-thio-dG successfully penetrates the mouse brain and causes chromosome damage to patient-derived DIPG brain tumor cells in mouse models of the disease. Laboratory models for preclinical treatment were derived from tumor cells donated by patients. Tumor cell telomeres are shown in red, telomere dysfunction in yellow and genomic damage is evident in green. Scientists from Cincinnati Children's reported research results in the journal Molecular Cancer Therapeutics.

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Cincinnati Children's

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