Schematic Model for the Role of Tandem UIMs in USP25 (IMAGE)

Tokyo Institute of Technology

Schematic Model for the Role of Tandem UIMs in USP25

Caption

By preferentially binding to the Lys48-linked ubiquitin chain (Lys48-Ub)-conjugated substrate, the tandem UIMs hold it close to the catalytic site of the enzyme which then cleaves Lys48-Ub more readily than Lys63-Ub.

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Tokyo Institute of Technology

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