Spindle Assembly Key to Chromosome Errors in Human Eggs (4 of 6) (VIDEO)

American Association for the Advancement of Science (AAAS)

Caption

Meiosis in a live human oocyte. Live human oocyte expressing H2B mRFP1 (chromosomes) and EGFP MAP4 (microtubules). The magenta/green spheres in the cytoplasm correspond to autofluorescent lipofuscin bodies frequently present in human oocytes. Scale bar, 10 μm. Time displayed in hours; NEBD (nuclear envelope breakdown) at two hours. This material relates to a paper that appeared in the June 5, 2015 issue of Science, published by AAAS. The paper, by Zuzana Holubcova at the Medical Research Council in Cambridge, UK, and colleagues was titled, 'Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes.'

Credit

[Credit: Zuzana Holubcova and Melina Schuh, MRC Laboratory of Molecular Biology]

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