Threefoil Designer Protein that Withstands a Range of Stresses (IMAGE)
Caption
Researchers at the University of Waterloo have discovered a new way to create designer proteins that have the potential to transform biotechnology and personalized medicines.
Using extensive experimental and modeling analyses the team show that ThreeFoil, a small glycan binding protein without disulphides (pictured left), exhibits outstanding kinetic stability against chemical denaturation and proteolytic degradation.
The "ribbon" (coloured grey and blue) represents the structure of the protein (called "ThreeFoil"). In yellow are "ligands" to which ThreeFoil specifically binds functionally. In red are stresses that ThreeFoil is resistant against: (from top to bottom) heat or high temperature, chemical denaturants, detergents, and proteases.
Credit
University of Waterloo
Usage Restrictions
None
License
Licensed content