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AlphaMed Press

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A bioengineered scaffold containing hypoxia-preconditioned, allogeneic human MSCs combined with a beta-adrenergic antagonist, timolol, to treat diabetic wounds in mice. The optimized treatment improved re-epithelialization by 65.6% with the beneficial effects of decreasing inflammation and promoting angiogenesis. This study provides preclinical evidence supporting the translation of this MSC-based treatment as a therapy for patients with chronic wounds.

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AlphaMed Press

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