Graphical Abstract (IMAGE)
Caption
SUCLA2 gene is frequently involved in the deletion of RB1 gene region, which occurs in 10 - 30 % of advanced prostate cancers. SUCLA2 deletion gives rise to a metabolic vulnerability. By screening chemical compounds, thymoquinone appeared to selectively kill SUCLA2-deficeint prostate cancer cells.
Credit
Kanazawa University
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