Effective Cleanup Is Needed for Brain Cells to Communicate Properly (IMAGE)

RIKEN

Effective Cleanup Is Needed for Brain Cells to Communicate Properly

Caption

A pileup of p62 under certain pathogenic conditions acts as a sink for GABARAPs, thereby preventing them from their normal functions of transporting GABAA receptors to the cell's surface. The reduction of GABAA receptors on brain cells prevents them from receiving inhibitory messages from their neighbors, in turn causing them to become hyperactive. When different brain regions cannot communicate with each other effectively, it ultimately leads to behavioral deficits often served in patients with autism or schizophrenia.

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RIKEN

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