Infrared spectra at different points of time (0-79 min) after the poly(ADP-ribosyl)ation reaction started (IMAGE)

University of Konstanz

Infrared spectra at different points of time (0-79 min) after the poly(ADP-ribosyl)ation reaction started

Caption

Infrared spectra at different points of time (0-79 min) after the poly(ADP-ribosyl)ation reaction started due to the addition of PARP1 substrate NAD+. The following can be observed: the dynamic formation of the biopolymer poly(ADP-ribose) (absorption bands at 1236 cm-1 and 1074 cm-1) and the detachment of PARP1 from the DNA strand break (absorption bands at 1645 cm-1 and 1548 cm-1).

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Modified from Krüger et al.,

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