Klf4 Isomer Effects On Reprogramming (IMAGE)

Center for iPS Cell Research and Application - Kyoto University

Klf4 Isomer Effects On Reprogramming

Caption

(top) Adding 9 amino acids before Klf4 to switch the isoform from Klf4S to Klf4L subtly lengthens the transgene. (bottom left) This lengthening causes a significant increase in the Klf4 protein expression. (bottom right) It also increases the proportion of reprogrammed cells (green) to partially reprogrammed cells (red).

Credit

Dr. Knut Woltjen's Laboratory

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