Improving survival in pancreatic cancer (IMAGE) Nagoya University Caption Kondo and his team found TUG1 overexpression in some pancreatic cancer patients leads to increased release of an enzyme (DPD), which breaks down the chemotherapeutic, 5-FU, into a compound that can't kill cancer cells. Targeting this pathway reduced chemotherapy resistance in mice. Credit Yutaka Kondo Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.