Neuronal Circuitry (IMAGE)

Cincinnati Children's Hospital Medical Center

Neuronal Circuitry

Caption

This microscopic image shows the presence of basic myelin protein and normal oligodendrocyte cell differentiation in the brain of a mouse. The cells form a protective sheath of insulation around nerves in the outer layers of the brain. Researchers report in Developmental Cell that mutation or loss of a gene called CHD8 hinders formation of the sheath in developing oligodendrocytes, causing neurological defects in the animals. CHD8 is one of the highest risk-susceptibility genes for autism.

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Cincinnati Children's

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