Hypothesis Illustration (IMAGE)

Rensselaer Polytechnic Institute

Hypothesis Illustration

Caption

Novel mechanism in diseases: zinc deficiency can enhance Hedgehog (Hh) ligand production and activate Hh signal pathway. Zinc deficiency is well known in prostate cancer, lung cancer, ovarian cancer and autism, where Hh activation is also observed, but a mechanistic link between zinc and Hh has never been previously demonstrated.

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RPI

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