Key Stages of Therapeutic Discovery and Development (IMAGE)

IOS Press

Key Stages of Therapeutic Discovery and Development

Caption

Key stages of therapeutic discovery and development and associated objectives aimed at improving the probability of technical success. Note the specific utility of biomarkers to inform preclinical and clinical decisions during each stage. DMPK, drug metabolism and pharmacokinetics; ID, identification; PK, pharmacokinetics; PoC, proof of concept; PoM, proof of mechanism; TE, target engagement.

Credit

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

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