Feeling the Pressure: How Blood Vessels Sense Their Environment (IMAGE)

University of Tsukuba

Feeling the Pressure: How Blood Vessels Sense Their Environment

Caption

A model illustrating the Thbs1/integrin/YAP signaling pathway in remodeling of vessel walls. Cyclic stretch induces secretion of Thbs1, which binds to integrin αvβ1 and aids in the maturation of FA-actin complex, thereby mediating nuclear shuttling of YAP via inactivation of Rap2 and Hippo pathway. In vivo, Thbs1/integrins/YAP signaling may lead to maturation of FA after TAC-induced pressure overload to protect the aortic wall. In contrast, Thbs1/integrins/YAP signaling leads to neointima (NI) formation upon flow cessation by carotid artery ligation. ECs: endothelial cells, SMCs: smooth muscle cells, EL: elastic lamella, LCA: left carotid artery.

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University of Tsukuba

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