Study Schematic (IMAGE)

RIKEN

Study Schematic

Caption

This study established an efficient method for conducting gene-rescue experiments in mutant mice. Applying the method to knock in a series of CRY1 mutants into Cry1-/-:Cry2-/- mice, researchers discovered that multisite phosphorylation around the flexible loop domains of CRY1 determine the period length of the mammalian circadian clock in vivo.

Credit

RIKEN

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credit RIKEN National Science Institute

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