Therapeutic Target on Shape-Shifting Enzyme (IMAGE)

National Institute of Standards and Technology (NIST)

Therapeutic Target on Shape-Shifting Enzyme

Caption

When efavirenz binds to CYP46A1 at the site shown in orange, it increases the flexibility of the protein in the region (magenta) around cholesterol (green). Regions with no changes are shown in grey and iron-containing heme in black.

Credit

Kyle Anderson/NIST

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