Working Memory Functional Activation (IMAGE) Radiological Society of North America Caption Working memory functional activation in healthy control subjects and patients with MTBI is shown. Surface-rendered projection on a representative atlas brain shows areas of activation in response to increased working memory load. Note the presence of increased activation in bilateral frontal and parietal regions, a finding consistent with activation of working memory circuitry in each group. A: In control subjects, visual comparison of working memory activation patterns shows more activation in women than in men, especially in the fron¬tal region. B: There is substantially less activation seen in female patients with MTBI than in female control subjects, and there is substantially more activation seen in male patients with MTBI than in male control subjects. C: At the 6-week follow-up study, female patients with MTBI showed a persistent hypoactivation pattern, whereas male patients with MTBI showed regression of hyperactivation and demonstrated a return to similar activation levels as those in male control subjects. Credit Radiological Society of North America Usage Restrictions May use with credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.