Salinosporamide A (IMAGE)

Technical University of Munich (TUM)

Salinosporamide A

Caption

Snapshots of a biochemical process -- obtained through X-ray crystallography -- provide insights that could guide development of tailored anti-cancer drugs. Researchers at the Technische Universitaet Muenchen and Nereus Pharmaceuticals have determined in detail how the bacteria-derived molecule Salinosporamide A disables the intracellular waste-processing plants called proteasomes. The researchers compare the mechanism to a key that breaks off in a lock.

Credit

TUM Dept. of Biochemistry and Nereus Pharmaceuticals.

Usage Restrictions

Courtesy TUM Dept. of Biochemistry and Nereus Pharmaceuticals, all rights reserved.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.