Membrane Proteins Interact with Their Host Cell Membrane (IMAGE)
Caption
Membrane proteins interact with their host cell membrane, which contributes to their preference for different functional states. This happens because membrane proteins, purple, change shape as they visit different functional states, top vs. bottom panels. When a molecule, such as an antiarrhythmic, the pink ovals with black tails, changes the properties of the cell membrane, represented by the blue circles with two tails, it also changes the membrane's interactions with the embedded proteins and thereby protein function, as indicated by the black arrows vs. red arrows. Therefore, antiarrhythmics that change the properties of bilayer will change function of diverse membrane proteins through this general, membrane-mediated mechanism.
Credit
Radda Rusinova/Weill Cornell Medical College
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