Bacterial Factories Release Checkpoint Inhibitors Locally to Safely Kill Tumors (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

Bacterial Factories Release Checkpoint Inhibitors Locally to Safely Kill Tumors (1 of 1)

Caption

A schematic showing how engineered bacteria (yellow) controllably release anti-PD-L1 and antiCTLA-4 nanobodies within tumors. This material relates to a paper that appeared in the Feb. 12, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by C.R. Gurbatri at Columbia University in New York, NY; and colleagues was titled, "Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies."

Credit

[Credit: C.R. Gurbatri et al., Science Translational Medicine (2020)]

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