Diagram of PROTACs' Mode of Action (IMAGE) Goethe University Frankfurt Caption A PROTAC is bifunctional and comprises a ligand (L, green) for the enzyme E3 ligase and a binding domain (L, red) for the target protein, connected via a short linker region (black) Credit Institute of Biochemistry II, Goethe University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.