Negative Feedback Mechanism Keeps Liver Fat in Check (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

Negative Feedback Mechanism Keeps Liver Fat in Check (1 of 1)

Caption

Deleting the PKD3 protein led to accumulation of cholesterol and triglycerides in the liver (bottom). This material relates to a paper that appeared in the Aug. 6, 2019, issue of Science Signaling, published by AAAS. The paper, by A.E. Mayer at University of Würzburg in Würzburg, Germany; and colleagues was titled, "The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling."

Credit

A.E. Mayer <i>et al., Science Signaling</i> (2019)

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