How Tissue Damage Causes Leaky Lungs (IMAGE)

American Association for the Advancement of Science (AAAS)

How Tissue Damage Causes Leaky Lungs

Caption

This figure displays a representative example of a lung from a mouse treated with either lipopolysaccharide (LPS), LPS+arginine-threonine-arginine (RTR) or saline control and then injected with Evan's blue dye intravenously to measure permeability in the lung (the more blue, the more leak). LPS increased the lung permeability and this was attenuated by the use of RTR, which acts to block PGP peptides. This material relates to a paper that appeared in the April 24, 2015, issue of Science, published by AAAS. The paper, by C.S. Hahn at University of North Carolina at Chapel Hill in Chapel Hill, N.C., and colleagues was titled, "The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability."

Credit

[Credit: Figure provided by Drs. Scott, Xu, and Winstead]

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