Immunotherapies without Side Effects? (IMAGE) Université de Genève Caption In yellow: liver macrophages, or Kupffer cells, which secrete the IL-12 protein that causes adverse effects of immunotherapy. In blue, blood vessels. Credit © UNIGE - Mikaël Pittet Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.