Breast Cancer Cells Use mTOR Signaling to Recruit Suppressor Cells to Promote Tumor Growth (IMAGE)
Caption
The mTOR pathway, an important pathway controlling cell growth and metabolism, is aberrantly activated in some breast tumors. This activation leads to increased expression of granulocytic colony formation factor (G-CSF, blue triangleEnglish ), which is then released into the circulation and stimulates the accumulation of myeloid-derived suppressor cells (MDSCs). MDSCs recruited to tumors directly enhance tumor initiation capacity. They also modulate the functions of other immune cells to dampen the anti-tumor immunity. RTK, receptor tyrosine kinase.
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X.Zhang
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