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Caption
The animation explains that insulin treatment of patients with diabetes reduces glucose levels, but it causes significant direct damage on the human arteries by activating oxidative stress. Treating patients with a DPP4 inhibitor "sensitizes" the human arteries and makes them respond in the opposite way to insulin, i.e. insulin reduces vascular oxidative stress, becoming from a detrimental to a beneficial intervention. This means that treatment with DPP4 inhibitors may allow insulin treatment to reduce the risk for heart attacks and strokes in diabetics. This material relates to a paper that appeared in the Apr. 29, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by I. Akoumianakis at University of Oxford in Oxford, UK; and colleagues was titled, "Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition."
Credit
[Credit: Oxford Translational Cardiovascular Research Group]
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