Central Illustration: Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells for Evaluating E-Cigarette Risk (IMAGE)

American College of Cardiology

Central Illustration: Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells for Evaluating E-Cigarette Risk

Caption

Mechanistic overview by which e-cigarette use might cause acute endothelial dysfunction. Exposure of endothelial cells to e-cigarette flavorings or serum of e-cigarette users leads to endothelial dysfunction associated with increased apoptosis,reactive oxygen species, and inflammation. ICAM ¼ intracellular adhesion molecule; IL ¼ interleukin; MCP ¼ monocyte chemoattractant protein; MCSF ¼ macrophage colony-stimulating factor; ROS ¼ reactive oxygen species.

Credit

Lee, W.H. et al. J Am Coll Cardiol. 2019;73(21):2722-37.

Usage Restrictions

May only be used with credit.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.