A Hydroxyurea Derivative Reversibly Blocks the Proteasome (IMAGE)
Caption
Biochemists at the Technische Universitaet Muenchen have identified a hydroxy urea motif as the lead structure of a new class of drugs that reversibly blocks the proteasome. To shed further light on this, the scientists conducted a crystal structure analysis. The outcome was that the hydroxyurea motif attacked the proteasome in a completely different manner than all other previously known inhibitors. Because of this property, the newly discovered structures work more specifically than other proteasome inhibitors and are thus expected to lead to less severe adverse side effects.
Credit
Chair of Biochemistry, Technische Universitaet Muenchen
Usage Restrictions
None
License
Licensed content